The central importance of solvent interactions in stabilization of specific protein structure has long been recognized decades ago tanford and kirkwood . Protein protein interactions ppis are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical . Protein solvent preferential interactions protein hydration and the modulation of biochemical reactions by solvent components. Protein folding and assembly can be manipulated in in vitro systems by co solvents at high concentrations a number of co solvents that enhance protein . Solvation effects upon the thermodynamic substrate activity correlation with the kinetics of enzyme catalyzed reactions ii more complex interactions of alpha
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